화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터)
권호 47권 1호
발표분야 의료용 고분자 부문위원회
제목 Dexamethasone loaded and biodegradable core-sheath biphasic monofilaments: Drug release and degradation studies
초록 Although biodegradable polymeric filaments have been widely used for biomedical applications, these still have some problems such as inflammation and mechanical properties. In our previous study, poly(L-lactide)-polydioxanone (PLLA-PDO) core-sheath monofilaments have been developed and characterized. In this study, mechanical properties, biodegradability, and the drug release of series of PLLA-PDO core-sheath monofilaments containing dexamethasone (Dex), an anti-inflammatory drug, were investigated. Biphasic structures showed the advancement of mechanical properties in the degradation process. Biodegradation could be controlled by biphasic structure and drawing process. PLLA-PDO monofilaments released Dex in sustained or controlled manners through the drug location in the biphasic structure and drawing rates. In conclusion, our drug-eluting sheath-core monofilament stents can be a promising model for advanced nonvascular stents, the targeted application of this study.
저자 양승원1, Myoung Jin Jang2, 손준식3, 정윤기1
소속 1한국과학기술(연), 2한국섬유(연), 3한국섬유개발(연)
키워드 core-sheath monofilament; drug-eluting stent; polydioxanone; poly (L-lactic acid)
E-Mail ykjoung@kist.re.kr