화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터)
권호 42권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Intracameral delivery of azidobenzoic acid-modified chitosan for development of a rat glaucoma model
초록 In this study, we propose intracameral delivery of azidobenzoic acid-modified chitosan (Az-CH) to develop a rat glaucoma model. For this, we pursued to chronically elevate the intraocular pressure(IOP) and thus, after intracameral injection of Az-CH in rats, we applied UV irradiation to photo-crosslink the Az-CH in the eye. To test this approach, we employed 24 eyes from 12 rats, which were divided into six distinct groups: 2 mg/ml Az-CH with UV, 10 mg/ml Az-CH with UV, 2 mg/ml Az-CH without UV, 10 mg/ml Az-CH without UV, no Az-CH with UV and normal control. After treatment, the change in IOP was monitored weekly, using a TonoLab® tonometer. The best result in IOP elevation was observed with the 10 mg/ml Az-CH with UV irradiation group (218.0%), which was maintained for up to 3 weeks after treatment. Therefore, we conclude that intracameral delivery of Az-CH, followed by photocrosslinking via UV irradiation, can effectively induce chronic IOP elevation to develop a rat glaucoma model.
저자 김세나1, 김대우2, 민창희1, 박기호1, 최영빈1
소속 1서울대, 2경북대
키워드 chitosan; glaucoma model; azidobenzoic acid; intracameral delivery
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