| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
The perfusable microfluidic devices for scaling up of 3D vascular construction |
| 초록 |
Scaling up of 3D vascularized tissues containing blood vessels is critical factor to be overcome in tissue engineering field. However, constructing cells and tissues over 500 um in thickness is pretty challenging due to lack of effective delivery of nutrient and oxygen to all tissue regions. Herein, we studied perfusable channeled device to fulfill the vascularized 3D tissue structure. The microfluidic device contains three perfusable channels (500 ㎛ diameter), and 3mg/ml collagen hydrogels were used as interstitial matrix. We introduced the co-culture system using HUVECs and mesenchymal stem cells (MSCs) to investigate the paracrine effect on stable vascularization by MSC in this system. Vascular channels formed by angiogenesis were further investigated to check channel interconnectivities through anastomosis. Our perfusable vascular bed can be applied to the drug screening or tissue regeneration studies. |
| 저자 |
이강원, 김상헌, 박귀덕, 윤다영, 박민희, 정홍수, 송보아
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| 소속 |
한국과학기술(연) |
| 키워드 |
microfluidic device; vascular construction; HUVEC; MSC
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| E-Mail |
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