| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
3D reconstructed stem cell environment for pancreatic tissue engineering |
| 초록 |
Current advances in treating pancreatic cell loss include islet replacement therapies or inducing cell proliferation rate in diabetes. Several drugs have been developed to induce β-cell proliferation, but they can have systemic cytotoxicity at high doses and are often non-selective – meaning they can also induce the proliferation of other cell types and dysregulate the hormone production in pancreatic islets. In this study, we propose developing proliferation-increasing prodrugs that selectively target high concentration of zinc ions in 3D reconstructed stem cell derived β cells. This can potentially reduce the side effects of known small molecules for β cell expansion toward a stem cell therapy for diabetic patients. |
| 저자 |
양기석 |
| 소속 |
인천대 |
| 키워드 |
pancreatic stem cells; 3D environment; screening platform; prodrug
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| E-Mail |
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