| 초록 |
Sonodynamic therapy (SDT) is an invasive therapeutic strategy, which induces the intracellular reactive oxygen species resulting in cancer-specific apoptosis. Although SDT has been emerged as a novel therapeutic strategy, it is hard to show sufficient therapeutic results because of the overexpressed anti-oxidants in the tumor microenvironment (TME). For this reason, the functional polymer was prepared to deplete glutathione (GSH), which is among of anti-oxidants in TME, and attached to the surface on titanium oxides (TiO2) for enhanced SDT. Under the irradiation of ultrasound, our nanoparticles induce more oxidative stress than conventional TiO2 nanoparticles by disrupting anti-oxidant ability at the intracellular level. Consequently, our GSH depleting polymer on TiO2 shows outstanding tumor growth inhibition in mice bearing tumor models. |
