| 초록 |
SIS has the potential for use as a good natural scaffold material because of the various cytokines and growth factors such as FGF-2. However, SIS is the lack of reliable and reproducible shape controllability is a drawback. To overcome this problem, micro/nanosized SIS powder was electrospun with a biodegradable and biocompatible polymer, polycaprolactone. PCL/SIS fibrous scaffolds and nerve conduit were fabricated with an electrospinning process. The hydrophilicity, mechanical properties, and cellular behavior of the PCL/SIS fibrous scaffold were analyzed. To observe the feasibility as a nerve tissue regeneration, nerve conduit was fabricated to composite aligned PCL/SIS fibrous through collector rotation. As the composite alignment of micro/nanofibers increased, the hydrophilicity, orthotropic mechanical properties, and cellular behavior of PC-12 cells were improved. The fabricated composite aligned PCL/SIS fibrous scaffold has the great potential for a good natural biomaterial. |
