| 초록 |
Sufficient functional restoration of damaged peripheral nerves is a big clinical challenge. In this study, we fabricated cellulose nerve conduit using the thermally induced phase separation (TIPS) and introduced reactive oxygen species (ROS) generator to promote nerve regeneration. Even though high level ROS can lead to cell death, low level ROS provide a beneficial effect such as accelerating cell proliferation. We choose protoporphyrin IX (PpIX) as a ROS generator, which was grafted onto the surface of cellulose nerve conduit (CEPP). This CEPP was designed to generate low level ROS during laser irradiation. We assessed the cytocompatibility of CEPP using Schwann cells, resulting that low level ROS promoted Schwann cell proliferation without cytotoxicity. Our results imply that CEPP will have great potential in peripheral nerve regeneration. |
