| 초록 |
The Peripheral nervous system (PNS) regeneration can be improved by nerve conduits. The purpose of this study was to design a more effective neural guidance conduit, to treat peripheral nerve into the conduit, and to determine regenerative capability through it in an in vitro model. A novel, fully biodegradable polymer conduit was designed and fabricated for use in peripheral nerve repair, which approximates the macro and microarchitecture of native peripheral nerves. A uniform shape based on poly(lactic-co-glycolic acid) (PLGA) and poly(γ-glutamic acid) (γ-PGA) has been prepared via a thermally induced phase separation technique using a mixture of dimethyl sulfoxide as solvent. The better nerve regeneration behavior in our nerve conduits may be caused by the effect of the asymmetrically porous tube with hydrophilicity, and structural stability, which can provide good environment for nerve regeneration and stimulation of the schwann cells. |
