| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 | 21권 2호 |
| 발표분야 | 생물공학_포스터 |
| 제목 | Synthesis and evaluation of natural compounds-peptide derivatives as potential anti-wrinkle agents |
| 초록 | As aging process continues in human skin, collagen production is reduced and fragmentation is increased, which is initiated by matrix metalloproteinase-1. Elastase is a degrading enzyme present in the dermis, and plays a role in the degradation of the ECM, which contains elastin. We developed natural compounds-peptides derivatives as potential anti-wrinkle agents which combined anti-oxidative small molecule and peptides have an effect on collagenase or elastase active sites. We synthesized 100 natural compounds-peptides derivatives by solid-phase peptide synthesis method. We evaluated anti-wrinkle activities of these natural compounds-peptide derivatives in vitro. Collagen synthesis assay, collagenase activity inhibition assay and elastase activity inhibition assay were performed using human fibroblast. Further efforts to verify their anti-wrinkle activities in vivo and their application for cosmetics are underway. |
| 저자 | 이혜숙, 김한영 |
| 소속 | 애경산업 |
| 키워드 | Anti-wrinkle agent; peptide; collagen; MMP-1; elastase |
