| 초록 |
Polymeric micelle, the self-assembly of block copolymers with core-shell architecture, is a promising nanodevice for drug and gene delivery. There are several relevant properties in polymeric micelle as nanodevice systems, such as longevity in blood circulation, tissue-penetrating ability, spatial and temporal controlled drug release, and reduced inherent toxicity. Also, engineering of the block copolymer structure allows the preparation of polymeric micelles with integrated smart functions, such as targetability as well as stimuli-sensitivity. This presentation overviews the recent achievements of polymeric micelles as smart nanodevices for drug and nucleic acid delivery to solid tumors. Then, the focus will be placed to the application of gene-loaded polymeric micelles as non-viral vectors in the field of regenerative medicine. Further, the future perspective will be addressed in the last part of this presentation, directing to the new medical paradigm of smart nanotheranostic systems controlled by external physical stimuli. |
