| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Photosensitizer loaded carbon dot to utilizing cancer therapy |
| 초록 | Photosensitizers (PS) induce cancer cell death through generated singlet oxygen and reactive oxygen species when laser irradiation. Tumor cell can secrete damage-associated molecular patterns (DAMPs) during death via photodynamic therapy (PDT). Therefore, PDT can be utilized as immunogenic cell death inducer. The carbon dots have lots of advance such as low toxicity, good water solubility and biocompatibility. Also, carbon dots could easily modify surface. In this study we developed PS loaded pH sensitive carbon dot (PS@c-dot) to release and accumulated PS into tumor site. We demonstrated that accumulation PS@c-dot to tumor site via enhanced permeability and retention effect. The PS@c-dot induces not only cancer cell death but also immune response through PDT. Therefore, the PS@c-dot could eradicate metastasis tumor through immune response. |
| 저자 | 박소연, 나건, 김다혜, 서정덕 |
| 소속 | 가톨릭대 |
| 키워드 | photodynamic therapy; cancer immunotherapy; pH sensitive nano material |
