| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
[특별세션] 국가과학기술연구회 융합클러스터: 나노융합기술의 뇌 과학 연구 동향 |
| 제목 |
Cognition and control using optogenetic approach |
| 초록 |
Cognitive flexibility is a fundamental feature of high-level brain function. However, neuronal pathways that control flexibility and the mechanisms by which flexibility is encoded are unknown. Fundamental questions underlying cognitive flexibility would be to understand a specific brain condition where new information can be updated without losing existing memories. In brief, we identified the direct long-range projection from the DRN to the OFC anatomically and functionally. Optogenetic stimulation of serotonergic inputs to the OFC facilitated the RL and the inhibition of DRN-OFC circuits slowed down the speed of RL. We also found that the membrane potential of pyramidal neurons was increased by serotonin, resulting in the enhanced spiking probability of the OFC network. Thus, we believe that these findings are important early steps which will furnish new insights into general cognitive learning. |
| 저자 |
현정호 |
| 소속 |
DGIST |
| 키워드 |
cognitive flexibility; serotonin; OFC; reversal learning; optogenetics
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| E-Mail |
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