| 초록 |
In recent years, there has been a growing interest in the development of stimuli-responsive hydrogels that can respond to specific stimuli, rather than the construction of static networks. Stimuli-responsive scaffolds are defined as scaffolds that undergo significant physical or chemical changes upon small alteration of external stimuli or changes within their environment. Using stimuli-responsive biodegradable scaffolds as cell transplant matrix provides a novel transplant method without surgical operation. The polymer solution with the cell can be injected into the tissue defect part, then hydrogel can be formed by stimuli to let the cell grow. By using biodegradable polymers, such as poly(lactic acid) (PLA) and poly(γ-glutamic acid) (PGA), the scaffold will degrade in vivo after tissue regeneration. Since different tissues have different mechanical properties, the gel strength and gelation time are important for designing stimuli-responsive biodegradable scaffolds. In this study, we developed novel stimulus-responsive hydrogels using bio-based biodegradable polymers, PLA and PGA. |
