| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Novel peptide-conjugated liposome for multimodal cancer therapy |
| 초록 |
Multi-modal therapeutics is the key for efficient and effective cancer therapy due to targeting ability, multiple cargo loading (i.e. gene therapy and chemotherapy) and synergistic effect of encapsulated drugs and siRNA. Here, we report a novel nanoliposomal system comprising anionic liposomal system (~100nm) with cancer cell specific targeting ability (novel bipodal peptide binder) and encapsulating both siRNA and chemotherapeutic drug (Paclitaxel) simultaneously. By using U87MG and MCF7-ADR cell line as model cancer cell line, we demonstrate the ability of this nanoliposome to specifically target cancer cells able to encapsulate high amount of siRNA and paclitaxel. The knockdown effect of siRNA by our nanoliposomal system is comparable to commercially available lipofectamine. Taken together, all these results suggested that our delivery system has high potential for multimodal cancer therapeutics, efficient and effective. |
| 저자 |
페이어, 전상용, 김성현, 유미경, 이인현, 이진주, 박진호
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| 소속 |
광주과학기술원 |
| 키워드 |
liposome; siRNA; gene therapy and chemotherapy
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| E-Mail |
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