| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation and Characterization of Deoxycholic Acid-Conjugated Low Molecular Weight Water-Soluble Chitosan Nanoparticles for Hydrphobic Antifungal Agent Carrier |
| 초록 |
To develop carrier of hydrophobic antifungal agents based on low molecular weight water-soluble chitosan (LMWSC), LMWSC was chemically modified with deoxycholic acid (DA) which is one of the bile acid as a hydrophobic group. The nanoparticles (WSCDA) using DA conjugated LMWSC were characterized using dynamic light scattering(DLS) and transmittance electron microscope (TEM). The particle size of WSCDA ranged from 250 to 350 nm and increased with the number of DA substitution. The loaded itraconazole as an antifungal agent WSCDA nanoparticles (WSCDA-ITCN) were prepared by solvent evaporation method. The drug content and the loading efficiency were investigated approximately 9 ～ 10% and 61 ～ 68% by UV spectrophotometer, respectively. It showed that the WSCDA-ITCN has the superior potential for the application as an antifungal angents. |
| 저자 |
정현, 남정표, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
LMWSC; Deoxycholic acid; Antifungal; Itraconazole; Drug carrier
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| E-Mail |
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