| 학회 |
한국화학공학회 |
| 학술대회 |
2004년 봄 (04/23 ~ 04/24, 공주대학교) |
| 권호 |
10권 1호, p.734 |
| 발표분야 |
열역학 |
| 제목 |
Hydrotropes and Polymers: Application of Hydrotropic Property to Hydrotropic Polymeric Micelles |
| 초록 |
Hydrotropic agents are freely soluble organic compounds which at a concentration sufficient to induce a stack-type aggregation, considerably enhance the aqueous solubility of organic substances, practically insoluble under normal conditions. Our approach here is to develop a new concept of hydrotropic polymeric micelles, which can be defined by combined properties of hydrotropy and micellar solubilization. We were interested in whether the introduction of polymeric forms of an identified hydrotrope into the cores of micelles could provide a solubilizing capacity for poorly soluble drug superior to existing polymeric micelle systems. Well-defined amphiphilic diblock copolymers, consisting of poly(ethylene glycol) (PEG) as a hydrophilic block and DENA-containing poly(2-(4-vinylbenzyloxy)-N,N-diethylnicotinamide) (P(VBODENA)) as a hydrophobic block, were successfully synthesized. Poorly soluble drug, Paclitaxel was efficiently loaded into PEG-b-P(VBODENA)s micelles by dialysis method, and the loading content of paclitaxel varied depending on the type of organic solvents block, block compositions and the initial feed weight ratio of paclotaxel to polymers. This study shows that polymeric micelles with hydrotropic structure have a high solublizing capacity with a long-term stability. |
| 저자 |
정재현1, 이상천1, 이재휘2, 조용우2, 허강무3, 박기남3, 김종득1
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| 소속 |
1KAIST, 2Akina Inc., 3Purdue Univ. |
| 키워드 |
hydrotropes; polymeric micelle;
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
