화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관)
권호 34권 2호
발표분야 의료용 고분자 부문위원회
제목 Chondrocyte Culture Using a Nanofiber-Hydrogel Composite System
초록 Cartilage is a flexible connective tissue covering the end part of bones in joints. Cartilage has a limited capacity for self-repair. Therefore, tissue engineering approach is necessary for the treatment. In this study, a nanofiber-hydrogel composite system has been investigated as a cell and growth factor carrier for cartilage tissue engineering applications. Rabbit articular chondrocytes and transforming growth factor-β1 (TGF-β1) were mixed with the precursors of a heparin-based hydrogel. The mixture was then seeded onto a roll-type scaffold made of electrospun PLCL/gelatin fibers. The nanofiber-hydrogel composite system showed more improved cell seeding efficiency and enhanced chondrocyte-specific gene expression by real-time RT-PCR than those prepared without hydrogel. Results indicate the potential of the PLCL nanofiber-heparin hydrogel composite system for cartilage tissue engineering. Acknowledgement: Financial support by Research Center for Biomolecular Nanotechnology, GIST
저자 홍보희1, 김미혜1, 이종만1, 전장수2, 김영하1, 태기융1
소속 1광주과학기술원 생체적용나노기초기술연구센터 / 광주과학기술원 신소재공학과, 2광주과학기술원 생체적용나노기초기술연구센터 / 광주과학기술원 생명과학과
키워드 Chondrocyte; PLCL nanofiber-heparin hydrogel; Cartilage tissue engineering
E-Mail gytae@gist.ac.kr