| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 | 25권 2호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Cancer therapy with stem cell based immunomodulator |
| 초록 | Over the past decades, photodynamic therapy (PDT) has been verified their capability to trigger the immune system for cancer treatment. Furthermore, nanotechnology-based immunotherapy has been investigated to enhance the therapeutic efficacy of PDT. However, PDT has some limitations such as toxicity and short half-life. To resolve the limitations, we fabricated human mesenchymal stem cell (hMSC) based immunomodulator. We engineered the hMSC surface and conjugated the polymer and photosensitizer (hMSC-PP). This compound can migrate to the cancer and make them secrete pro-inflammatory cytokines under specific wavelength of laser. These cytokines activate immune system by triggering IL-2,IL-4. Also under laser irradiation, hMSC-PP could accumulate cytokines at tumor without any side effects. With various experiments, we observed this compound could induce immune cells and increase cytokine concentration at tumor site. Thus, hMSC-PP showed their potential for cancer immunotherapy. |
| 저자 | 박나은, 김경섭, 이주영, 한지은, 황희숙, 이종환, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | photodynamic therapy; human mesenchymal stem cell; immunotherapy |
