| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Pro-oxidant drug-loaded chitosan-fucoidan nanoparticles for cancer-specific treatment |
| 초록 |
Pro-oxidant therapy that can trigger cytotoxic oxidative stress in cancer cells has gained great attention for cancer-specific therapy. Piperlongumine (PL) is one of the effective pro-oxidant drugs and induces cancer-specific apoptosis by increases the oxidative stress in the cell. However, its clinical use was limited owing to its hydrophobic nature. In this study, natural polymer-based chitosan-fucoidan nanoparticles (CS-F NPs) were prepared by ionic gelation in order to encapsulate hydrophobic PL. CS-F NPs showed minimal cytotoxicity in human prostate cancer cells (PC-3), demonstrating their great biocompatibility. PL-loaded CS-F NPs selectively increased intracellular reactive oxygen species (ROS) in PC-3 cells than in normal human dermal fibroblast cells (hDFB), thus resulting in selective cytotoxicity in PC-3 cells. This study demonstrates that CS-F NPs are effective natural polymer-based drug carriers for safe and selective cancer treatment. |
| 저자 |
최대건, Nguyễn Cao Thùy Giang, Trương Hoàng Quân, 홍지승, 심민석
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| 소속 |
인천대 |
| 키워드 |
nanoparticles; pro-oxidant therapy; chitosan; fucoidan; piperlongumine
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| E-Mail |
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