| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-나노 |
| 제목 |
Improved Dissolution Property of Poorly Water-soluble Drug Induced by Crystallization Confinement using ‘Porous Mannitol Template' |
| 초록 |
In the pharmaceutical industry, the problems of the poorly water-soluble drugs have been discussed. In this study, we proposed the solution for improving the dissolution property of the poorly water-soluble drugs through crystallization confinement performed by ‘Porous mannitol template’. The porous template was prepared by directional freezing and freeze drying in sequence. Because of the high viscosity of the mannitol aq. solution and rapid melt crystallization, the pores size of template was from hundreds of nanometer to tens of micrometer. The drug was undergone evaporation crystallization in theses pores and the volume of pores confined the growth of the drug particles. The particles size was analyzed by the Mie-Fraunhofer light scattering method. The size of particles decreased to less than 1um. The crystallization confinement of drug particles using porous mannitol template is an effective techniques to strength the dissolution property of poorly water-soluble drugs. |
| 저자 |
김현진, 이종휘
|
| 소속 |
중앙대 |
| 키워드 |
drug delivery system; confining crystallization
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| E-Mail |
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