| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Thrombin Activatable Peptide Conjugated Gold Nanoparticles for CT/NIRF Dual Imaging |
| 초록 |
Gold nanoparticles (AuNPs) are a unique material due to their controllable morphology, low cytotoxicity, surface plasma resonance effect and high X-ray absorption. For these reasons, AuNPs have studied and developed as an imaging probe. In this study, we developed thrombin activatable CT/NIRF imaging probe which can detect thrombosis in the blood stream. AuNPs were coated with silica layer to have stability and biocompatibility in human body. Then thrombin activatable peptide conjugated dye (Thr-dye) was conjugated to the nanoparticle surface. When the probe interacts with thrombin, the enzyme cleaves the peptide and dequenches NIRF dyes which can detect thrombosis. Therefore, AuNP part of the probe is used as CT imaging probe and the Thr-dye dequenching system is used as NIRF imaging probe. These feasibilities of biocompatible AuNPs as CT/NIRF dual imaging probe were showed by promising results for detecting thrombosis. |
| 저자 |
정솔1, 김정연2, 김동억3, 권익찬4, 김광명5, 안철희6
|
| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering, 4Seoul National Univ., 5Departments of Radiology and Experimental Diagnostic Imaging, 6Dongguk Univ. Ilsan Hospital |
| 키워드 |
Gold nanoparticle; CT/NIRF dual imaging
|
| E-Mail |
|
