| 초록 |
Metal-Organic Frameworks(MOFs) are porous hybrid materials constructed by metal nodes and bridging organic linkers. MOFs with their exceptionally high surface area are potential candidates in various fields of application such as drug delivery system, catalysis, gas storage, sensing. Three types of water-stable, biocompatible MOFs(MIL-100(Fe), UiO-66(Zr) and MOF-5) were selected as drug delivery carrier of ibuprofen(isobutylpropanoic acid) which is a hydrophobic(logP=3.97) and commonly used nonsteroidal anti-inflammatory drug. Delivery of ibuprofen experiment was perfomed with different pH conditions at 36.5°C, under continuous bidimensional stirring. Synthesized MOFs were characterized by BET, XRD, EDX, FT-IR and UV-vis. |
