| 학회 | 한국화학공학회 |
| 학술대회 | 2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 | 25권 2호, p.1493 |
| 발표분야 | 생물화공 (Biochemical Engineering) |
| 제목 | Melanin Decolorization Effect of Glutathione Peroxidase (GPX) in Lysosome-related Organelle Extract (LOE) Isolated from S. cerevisiae |
| 초록 | Melanin compounds have a function to protect skin by harmful ultraviolet ray, but too much synthesis of them can make the skin dark and unclean, and lead to hyperpigmentation such as a melanism. In previous research, we found a melanin color reduction effect of lysosome-related Organelle Extract (LOE) from S. cerevisiae and that the melanin color reduction effect was related to peroxidase activity of LOE. In this study, melanin color reduction effect of Glutathione Peroxidase (GPX), a peroxidase in peroxisome, was confirmed and S. cerevisiae was constructed to highly express GPX protein tagged with green fluorescence protein. LOE isolated from the clone was more effective to reduce melanin color than wild type. These results provide insights into the regulation of GPX and LOE from S. cerevisiae as new cosmetic materials to reduce the color intensity of melanin. This research was supported by the Ministry of Trade, Industry & Energy(MOTIE), Korea Institute for Advancement of Technology(KIAT) through the Encouragement Program (P0006145) for The Industries of Economic Cooperation Region |
| 저자 | 전경찬1, 윤지희2, 민지호1, 김양훈1 |
| 소속 | 1전북대, 2화학공학부 |
| 키워드 | 생물화학공학 |
| 원문파일 | 초록 보기 |
