| 초록 |
Corneocytes represents the main water reservoir of stratum corneum, and that ability intimately arises from their architecture and total composition. Here we describe a novel method for fabricatinig a microgel-in-liposome (M-i-L) structure consisting of a sodium hyaluronate microgel and a lipid membrane envelop in order to mimic corneocyte cell structures. To demonstrate the applicability of this unique vesicle system, we encapsulated a high concentration of natural moisturizing factor in the microgel core and investigated how the M-i-L structure affected the water retention in comparison with other control systems. This experimental result inspired us to investigate how corneocyte cells, which feature a lipid-enveloped hydrogel structure, provide such long-lasting hydration to the skin. |
