| 초록 |
Multimodal nanocomposite probes have become increasingly prevalent over the past decade. Of these, magnetic particles with fluorescent probe are receiving the most attention due to their ability to combine two widespread techniques, magnetic resonance imaging (MRI) and confocal or dark-field microscopy, which are complementary in terms of three-dimensional imaging capability and spatial resolution, respectively. Herein, we used magnetic particles (MPs) with conjugated polymer dots coated with oligopeptide (CPdot@pep) for trypsin sensing. When the trypsin was added in MPs and CPdot@pep aqueous solution, p-arg was hydrolyzed, and then CPdots was aggregated with MPs due to surface charge interaction. As the result, CPdots was removed by MPs with magnetic field, and then fluorescence of solution was quenched. |
