| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 |
20권 2호, p.2454 |
| 발표분야 |
Engineered biomaterials with innovative technology symposium(생물화공부문위원회 주제별 심포지엄) |
| 제목 |
위치선택적인 알부민 결합을 통한 단백질 의약의 체 내 안정성 증대(Spatially-Controlled Albumin-Conjugation to Therapeutic Proteins for Prolonged Circulation Time In Vivo) |
| 초록 |
Proteins are bio-polymers with unique functionalities and have been widely used in diverse biotechnology fields. The advance in recombinant protein techniques enables the production of a large amount of proteins including therapeutic proteins and biocatalysts. In order to design recombinant proteins with novel properties, our research group has been exploring biosynthesis of artificial proteins using non-natural amino acid building blocks. Site-specific incorporation of a non-natural amino acid containing a reactive functional group into a target protein allows site-specific chemical modification of the protein. We employed the combination of the site-specific incorporation of a non-natural amino acid technique and click-chemistry in order to improve pharmacokinetic properties of (therapeutic) proteins. Extending the protein therapeutics serum half-life will significantly enhance the utility of existing protein therapeutics. |
| 저자 |
Inchan Kwon |
| 소속 |
School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) |
| 키워드 |
therapeutic protein; serum half-life; non-natural amino acid
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
