| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1610 |
| 발표분야 |
분리기술 |
| 제목 |
Characteristic of Monolithic Imprinted Column and Its Application for Separation of Xanthine Derivatives |
| 초록 |
Monolithic molecularly imprinted columns were designed and prepared for rapid separation xanthine derivatives caffeine, theobromine and theophylline by in-situ thermal-initiated copolymerization technique. Molecular recognition was found to be dependent on the stereo structures and the arrangement of functional groups of the imprinted molecule and the cavities on MIP. Some chromatographic conditions such as the composition of the mobile phase and the temperature were investigated and hydrogen bonding interaction and hydrophobic interaction played an important role in the retention and separation. Thermodynamic data (ΔΔH and ΔΔS) obtained by Van’t Hoff plots revealed an enthalpy-controlled separation. The morphological characteristics of the monolithic MIP were investigated by scanning electron microscope, whcih showed that both mesopores and macropores were formed in the monolith. The presents method is very simple compared with the conventional MIP procedure and its macroporous structure has excellent separation properties. |
| 저자 |
노경호, Hongyuan Yan
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| 소속 |
인하대 |
| 키워드 |
Imprinted monolithic column; Chromatographic characteristic; Xanthine derivatives; Recognition mechanism
|
| E-Mail |
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| 원문파일 |
초록 보기 |
