| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Anti-Flt1 Peptide Hyaluronate Conjugate for the Treatment of Retinal Neovascularization and Diabetic Retinopathy |
| 초록 |
Anti-Flt1 peptide of GNQWFI is an antagonistic peptide for vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1) inhibiting VEGFR1 - mediated endothelial cell migration and tube formation. In this work, anti-Flt1 peptide (G-GNQWFI) was chemically conjugated to tetra-n-butyl ammonium modified hyaluronate (HA-TBA) via amide bond formation in DMSO using BOP chemistry. The resulting HA GGNQWFI conjugate self-assembled to form micelle-like nanoparticles in aqueous solution. According to in vitro biological activity tests, HA GGNQWFI conjugate exhibited a dose-dependent inhibition effect on the binding of Flt1-Fc to VEGF165 coated on the well. Furthermore, anti-Flt1 peptide HA conjugate effectively inhibited retinal choroidal neovascularization (CNV) in laser induced CNV model rats. The retinal vascular permeability and the deformation of retinal vascular structure were also reduced in diabetic retinopathy model rats after treatment with anti-Flt1 peptide HA conjugate. |
| 저자 |
김혜민1, 한세광1, 오은주1, 최준섭2, 주천기2
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| 소속 |
1POSTECH, 2가톨릭대 |
| 키워드 |
Hyaluronate; Anti-Flt1 peptide; drug delivery; choroidal neovascularization; diabetic retinopathy
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| E-Mail |
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