| 초록 |
In this study, a hydrogel sensor for cancer detection was developed using ureidopyriminone-conjugated gelatin (Gel-UPy) containing diselenide-containing carbon dots (dsCD). In dsCD, diselenide bonds are cleaved by glutathione (GSH) or reactive oxygen species (ROS) to increase hydrogen bonds and affect the self-healing ability, conductivity and adhesion of Gel-UPy / dsCD hydrogels. Tumor conditions containing GSH and ROS (MDA-MB-231) show faster self-healing of hydrogels, unlike normal conditions (MDCK). Also, the formation of hydrogen bonds by cleavage of diselenide bonds affects the electrochemical signal. Gel-UPy / dsCD hydrogel shows excellent adhesion and in vivo cancer detection ability after exposure to GSH or ROS, which is similar to the results observed in low concentration environments. This work supported by Korea Institute for Advancement of Technology(KIAT) grant funded by the Korea Government(MOTIE) (P00008500, The Competency Development Program for Industry Specialist) |
