| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Wireless biosensor based TiO2/Cu2+ polymer dots for cancer targeting in response to visible light and Alkaline phosphatase |
| 초록 |
Herein, PD(HA)TiO2/Cu2+ was investigated for cancer targeting based on electrochemical approach. By mean of CD44 receptors overexpressed on the cancer membrane and distinctive PPi/ALP levels in intracellular environment, the biosensors altered the electronic resistance obtained by a smartphone. The antifouling effect of TiO2 promoted cancer detection via cell removal under visible light. The cancer-detached biosensors showed a higher resistance than the normal ones due to the dissociation of Cu2+ by high level of ALP/PPi in cancer cells with the cellular uptake by endocytosis. The biosensor displayed a sensitive method for cancer sensing with low LOD value compared to optical one. The wireless biosensor showed a potential approach to promote cancer diagnosis at early stage. This work was supported by Korea National University of Transportation in 2021. |
| 저자 |
응 우엔 응안장, 박성영
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| 소속 |
한국교통대 |
| 키워드 |
wireless sensor; enzyme responsive; antifouling; cancer detection
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| E-Mail |
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