| 초록 |
Photodynamic therapy (PDT) involves the application of a tumor-localizing photosensitizer which can make the excited electrons by local illumination of the tumor with a specific wavelength light. The excited photosensitizer can transfer its electron and energy to oxygen molecules in our body and generate the cytotoxic reactive oxygen species (ROS) such as singlet oxygen which can kill the cancer cell. Therefore, increasing of ROS concentration in the cancer cell can efficiently kill cancer. In the previous study, energy donor conjugated Ir(Ⅲ) photosensitizer (Ir-OA) can increased ROS production due to intramolecular energy transfer system. The Ir-OA can be folded by the sufficient length of hydrophilic linker and hydrophobic energy donor and acceptor. It makes the distance between donor and acceptor close, causing energy transfer to occur. Therefore, I will check the difference in energy transfer efficiency through the hydrophilic energy donor-acceptor linker length adjustment. |
