| 학회 | 한국재료학회 |
| 학술대회 | 2021년 가을 (11/24 ~ 11/26, 경주 라한호텔) |
| 권호 | 27권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | Biomechanical Evaluation of rhBMP-2 Grafted 3D Printing Scaffold for Induced Membrane Technique in Bone Defected Rabbit Model |
| 초록 | Induced membrane technique (IMT) with autogenous bone grafts (ABG) are considered as a gold standard with grafting material for the treatment of nonunion, but, traditional AMG is not enough to induce repair. Especially in managing patients whose donor sites have already been used up several times or the defect’s size is too large to overcome with ABG, as well as, many donor site problems occur while harvesting large volume of autogenous bone such as long-term pain, iatrogenic fracture, bleeding, neurologic injury, and infection. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable synthetic scaffolds to be used in place of ABG for the treatment without autologous tissue harvest. Therefore, we have hypothesized that rhBMP-2 and hydrogel applied on 3D printed bio-ceramic can have an effective IMT compared to traditional ABG treatment. To verify the effect of rhBMP-2 scaffold with compare to ABG in IMT, 16 number of rabbit femur bone defect models were used for micro computed tomography (uCT) and bio-mechanical test which can evaluate volume, density, static stiffness, dynamic stiffness, and viscoelasticity of regenerated bone, respectively. *Acknowledgements: This work was supported by 2017 ATC (Advanced Technical Research Center) grant (10077279) funded by the Ministry of Trade, Industry and Energy (MOTIE) of Korea. |
| 저자 | Yong-Hoon Jeong1, Tae-Gon Jung2, Kwan-Su Kang1, Whee-Sung Son2 |
| 소속 | 1Department of Medical Device Development Center, 2Osong Medical Innovation Foundation |
| 키워드 | Mechanical evaluation; BMP-2; stiffness; Viscoelasticity; uCT |
