| 초록 |
To effectively regenerate injured tissues, tissue engineers have focused their studies on making bioactive scaffolds. For this purpose, in situ cross-linkable hydrogel have potentials such as no requirement of toxic crosslinker as compared with preformed matrices. Heparin binds to growth factor and ECM proteins to promote cell adhesion. Herein, we present an in situ cross-linkable hydrogel composed of heparin and PLGA–PEG–PLGA as an injectable matrix for tissue regeneration. The thermosensitive hydrogel was prepared through Michael type addition between thiolated heparin and diacrylated PLGA–PEG–PLGA, showing the sol-gel transition behavior around 37℃. Characteristic results demonstrate that the addition of thiolated heparin to diacrylated PLGA–PEG–PLGA solution improved the bioactivity as well as the thermal and physical stability of the hydrogel. Therefore, our in situ cross-linkable hydrogel is potentially useful as bioactive injectable cellular matrix to tissue regeneration. |
