| 초록 |
As a natural polymer, alginate’s performance as a biomaterial is limited by its tendency to be largely contaminated. In addition, the industrial processes used for extracting alginates from seaweed could introduce further contaminants into the raw alginates. Some of these impurities include endotoxins, certain proteins and polyphenols. Moreover, endotoxins and proteins have been associated with a reduced biocompati- bility of the alginate. Therefore, a key element in the validation of the alginate for implantation purposes is an efficient purification process to monitor and remove all its contaminants. The aim of this study was to develop a purified, highly biocompatible, and highly stable alginate from commercially available alginate. We analyzed the properties such as visco- sity of alginate before and after purification and cell viability. In result, we conclud from this study that alginate purification improve the viability of cell. This research was supported by WCU (R31-20029). |
