| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Substrate-tethered artificial membranes with functional membrane proteins |
| 초록 |
Manipulating a cell/tissue interactive surface is a crucial way to develop long-term implantable materials. Here, we produced particular interfaces with cellular membrane proteins to modulate selective interactions with inherent cells. In the first study, for the fabrication of a neuro-specific interface, neural-specific cell adhesion molecules (CAM,L1) containing vesicles extracted from differentiated PC-12 cells was used to formed a lipid bilayer tethered on titanium surface. The modified surface was successful in air stability and biofouling standpoints. In-vitro study confirmed that modified substrate provides a highly biocompatible surface for neuron cells; in contrast, it limits the astrocyte cell activation and local inflammation. In the second study, we are investigating on lipid bilayers incorporating galectin-1 protein (Gal-1). |
| 저자 |
MD LEMON HASAN1, 김가을2, 정윤기2
|
| 소속 |
1Korean Institute of Science and Technology, 2KIST |
| 키워드 |
tethered lipid bilayer; L1 cell adhesion molecule; membrane protein; galetin-1 protein
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| E-Mail |
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