| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
분자전자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
π – Extended, π – Fused and Non-fused tetra substituted imidazole derivatives: Studies of photophysical properties, versatile biological activities and molecular docking |
| 초록 |
We report a series of imidazole based fluorescent dyes and their photophysical properties in particularly ESIPT. The impact of structural variation on photophysical properties and their association with solvent’s polarity and proticity were throughly investigated by comparing with their analogues of blocked ESIPT functionality. We have investigated their photophysical properties, using experimental transient absorption and theoretical DFT/TDDFT. Besides, the urease inhibitory activity of these compounds against Jack bean urease was also studied. All but one of the obtained compounds displayed inhibitory potential, as demonstrated by highest inhibition activity (0.0288±0.0034). Docking stimulation was performed to into the crystal structure of Jack bean urease and caprin protein at the active site to the probable binding mode. Furthermore, anti-cancer activity of imidazole derivatives were peformed by MTT analysis towards stomach cancer cell lines (AGS). |
| 저자 |
Eswaran Kamaraj1, 박상혁2
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| 소속 |
1Kongju National Univ., 2공주대 |
| 키워드 |
tetra substituted imidazoles; ESIPT; DFT/TD-DFT; Urease inhibition; caprin protein; molecular docking.
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| E-Mail |
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