| 초록 |
Tumor necrosis factor levels of blood are closely related to the prognosis of autoimmune diseases. Therefore, we developed an apta sensor that can detect TNF in human serum without the labeling process. The aptasensor proposed has a multifunctional DNA probe immobilized on a gold electrode. The multifunctional DNA probe consisted of a TNF aptamer sequence, a C-C mismatch sequence in which the redox label is located, and a sequence modified with a thiol group for electrode immobilization. Acknowledgements: This work was supported by the National Research Foundation of Korea grant funded by the Korea government and by Korea Environment Industry&Technology Institute through the program for the management of aquatic ecosystem health, funded by Korea Ministry of Environment and by the Industrial Core Technology Development Program funded by the Ministry of Trade, Industry and Energy. |
