| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Therapeutic gene delivery of using stem cells as tumor specific non-viral vector and photochemical internalization |
| 초록 |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising therapeutic protein to induce tumor apoptosis. TRAIL gene is delivered by non-viral vector due to short half life and low stability. However, gene delivery using non-viral vector has limitation on serum stability and target specificity to tumor. To overcome the limitation of gene delivery using non-viral vector, human mesenchymal stem cells (hMSCs) and photochemical internalization (PCI) strategy were utilized for targeting tumor and enhanced transfection efficiency. We substantiated that homing ability of hMSCs could enhance tumor targeting and PCI-mediated TRAIL gene loading in hMSCs induced TRAIL gene expression at tumor site. Also, the xenograft mouse model was observed that TRAIL protein was released from hMSCs efficiently after condition of laser irradiation leading to a valuable therapeutic efficiency as an antitumor effect. |
| 저자 |
박소연, 한지은, 황희숙, 나건
|
| 소속 |
가톨릭대 |
| 키워드 |
gene delivery; TRAIL; PCI; non-viral vector
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| E-Mail |
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