| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Pluronic Mixture with Thermo-sensitivity and Residence Stability as a Postsurgical Tissue Adhesion Barrier |
| 초록 |
The formation of adhesions between a traumatized tissue and surrounding organs is a frequently occurring undesirable result after surgery. Various synthetic and natural polymeric materials as tissue adhesion barriers have been investigated. In this study, sol–gel transition temperature-controllable Pluronic F127/F68/P123 were prepared to evaluate their potential as tissue adhesion barrier gels. The sol–gel transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68/P123 ratio and polymer concentrations. The Pluronic P123 which can improve the micelle stability of Pluronic F127 provided residence stability of the Pluronic mixture gels in the body. The sol-gel transition temperature and residence stability in the PBS of the Pluronic mixtures with different polymer ratio and concentration were investigated. The in vivo animal study using a rat model was also carried out to evaluate the anti-tissue adhesion effect of the prepared Pluronic mixtures. |
| 저자 |
강준구, 오세행, 나승연, 이진호
|
| 소속 |
한남대 |
| 키워드 |
Tissue Adhesion Barrier; sol–gel transition; Pluronic P123
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| E-Mail |
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