| 초록 |
Transdermal antigen delivery is a convenient pathway for delivering antigens or immunomodulators to immune cells (e.g., macrophage, dendritic cell). Especially, dermal dendritic cell activates T cells as a representative antigen presenting cell. However, skin penetration of huge molecules is hardly achieved due to stratum corneum (SC), in which keratinocytes are tightly bound by proteins and lipids. Therefore, diverse materials (e.g., liposome, micelle, solid-lipid nanoparticle) have been explored for transdermal drug delivery. Recently, polymeric nanogels have received great attention as a transdermal drug delivery carrier. In this study, we prepared ovalbumin-loaded pectin nanogels via thiol-norbornene photo-click crosslinking. The pectin nanogels have a uniform size of ~200 nm and cytocompatibility. In skin penetration test the nanogels were successfully delivered to dermis through SC, indicating the pectin nanogels is a promising candidate as a transdermal antigen delivery carrier. |
