| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 기능성 고분자 |
| 제목 | Controlling permeability of weak polyelectrolyte multilayer films. |
| 초록 | The new development of layer-by-layer assembled polyelectrolyte(PE) multilayer films over the past decade may prove useful in the arena of novel drug delivery systems. The fabrication of polyelectrolyte mulatilayer thin films on solid substrate has proven to be an experimentally simple and versatile method to produce nanoscopically structured materials. The focus of this work is to study the permeability control of the multilayer films for drug delivery applications. The release behavior would be dependent on the permeability of the multilayer shell. These multilayer shells have been found to be permeable to small molecular weight dyes and ions. A cationic dye, Rhodamine 6G(R6G) was used as model drugs to assess the loading and release by poly(ethylene-alt-maleic anhydride)(PEMAh)/poly(4-vinyl pyridine)(P4VP) multilayer films. PEMAh/P4VP multilayers assembled at pH = 5.5/8.0 loaded buffered R6G (pH 4.2) throughout the multilayers due to the available carboxylate binding sites within the film and a permeable structure. The amount of R6G loaded in multilayer film increased with increasing film thickness. pH-sensitive release behavior, where lower pH environments increased the release rate and release amount. We investigated that the permeability of additional capping layers was able to control the release rate of R6G. Figure 1 shows the effect of PEMAh/poly(ethyleneimine) (PEI) capping layers on PEMAh/P4VP multilayers. The PEMAh/PEI capping layers slow the rate of R6G dye release. The addition of the capping layers prove to be an effective physical barrier. Other methods including cross-linking of the capping layers and the addition of clay nano particles to control permeability of the (PEMAh/P4VP) multilayer films will be presented. Fig.1. Comparison of the release profiles of R6G dye from (PEMAh/P4VP)10.5 multilayer and (PEMAh/PEI)3 capped (PEMAh/P4VP)10.5 multilayer immersed in aqueous solutions of varying pH. |
| 저자 | 홍숙영, 이준열 |
| 소속 | 경희대 |
| 키워드 | layer-by-layer; polyelectrolyte multilayer; permeability |
