| 초록 |
Experimental studies were carried out for the gas bubble-assisted extraction of paclitaxel from Taxus chinensis while varying parameters such as gas flow rate, bubble size, and contact time. As the gas flow rate increased, the paclitaxel yield increased. The yield of paclitaxel increased with increasing bubble size at a given gas flow rate. Extraction efficiency has been dramatically improved, and the time required for extraction has been reduced compared to conventional methods. As a result of investigating the mechanism of extraction in which gas bubbles were introduced, it was found that the bubble itself contributes to the improvement of extraction efficiency. In addition, the extraction behavior was quantitatively investigated by calculating the effective diffusion coefficient and mass transfer coefficient of paclitaxel. [This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186).] |
