| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-콜로이드·계면화학 |
| 제목 | Wide-range detection of 25-hydroxyvitamin D3 using polyethylene-glycol-free gold nanorods based on localized surface plasmon resonance |
| 초록 | Deficiency of vitamin D cause various diseases such as obesity, digestive problems, osteoporosis, and depression. Vitamin D3 hydroxylates to 25-Hydroxyvitamin D3 in the liver, so that the measurement of 25-Hydroxyvitamin D3 in the blood demonstrate the level of vitamin D3 in the body. Typically, the average level of 25-Hydroxyvitamin D3 in the blood is 20-80 ng/mL. In this study, we developed a localized surface plasmon resonance (LSPR) aptasensor using polyethylene-glycol(PEG)-free gold nanorods (AuNR) for the wide-range detection of 25-hydroxyvitamin D3. We exchanged the stabilzer of AuNR from surfactant to citrate instead of PEG. This modification caused the AuNRs are more effectively immobilized on the substrate. Thereby our LSPR aptasensor was enabled a detection over a wide concentration range of 0.1– 105 ng/mL, with 0.1 ng/mL limit of detection. The PEG-free AuNR based LSPR aptasensor afford a new technology for the development of robust sensing technique for vitamins. |
| 저자 | 조성재, 권오석 |
| 소속 | 한국생명공학(연) |
| 키워드 | 25-hydroxyvitamin D3; localized surface plasmon resonance; aptasensor; PEG-free gold nanorods |
