| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Bioimaging of Flt1 Peptide – Hyaluronate Conjugate Micelles for Therapeutic Applications to Ocular Diseases |
| 초록 |
The eyeball has a complex structure with tight barriers limiting ocular penetration of topically delivered drugs. The residence time of drug carrier in the cornea must be prolonged to enhance the bioavailability of ocular therapeutics. In this work, we carried out bioimaging of Flt1 peptide – hyaluronate (HA) conjugate micelles for therapeutic applications to ocular diseases. The micelles were labeled with HiLyte 647 amine encapsulating a model drug of hydrophobic 5(6)-carboxyfluorescein diacetate N-succinimidyl ester (CFSE). After eye drop of these micelles into rodent eyes and the following enucleation, their long-term distribution in the cornea was clearly visualized by confocal microscopy of sectioned tissues and in vivo real time bioimaging via two photon microscopy. From the results, we could confirm the feasibility of Flt1 peptide – HA conjugate micelles for the treatment of corneal diseases and possibly other ocular diseases. |
| 저자 |
백송은, 김혜민, 한세광
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| 소속 |
포항공과대 |
| 키워드 |
Hyaluronate; Flt1 peptide; Conjugate; Two photon microscopy; Ocular diseases
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| E-Mail |
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