| 학회 |
한국재료학회 |
| 학술대회 |
2013년 가을 (11/06 ~ 11/08, 제주롯데호텔) |
| 권호 |
19권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Fabrication and characterization of BMP-2 and VEGF coated on Gelatin- Pectin- BCP composite as scaffold for bone regeneration |
| 초록 |
In this study, composite of Gelatin (Gel)-Pectin (Pec)-biphasic calcium phosphate (BCP), scaffolds were fabricated successfully for bone regeneration. Then two type of growth factor BMP-2 and VEGF coated on surface of scaffold. The incorporating of bone morphogenetic protein (BMP-2) and vascular enthedlidal growth factor (VEGF) promoted osteoinduction in Gel-Pec-BCP was developed for bone induction. The physical properties were examined by scanning electron microscopy (SEM), porosity, Fourier transform infrared spectroscopy (FT-IR) and X-ray Diffraction (XRD). In vitro experiment was done by studying of cytotoxicity using MTT assay, and immunoflourescene for cell behavior. In vivo study was done by implantation in rat model, it is concluded that our modified scaffolds hold a great candidate for bone tissue engineering application. |
| 저자 |
Jhaleh Amirian1, Nguyen Thuy Ba Linh2, Young-Ki Min3, Byong Taek Lee1
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| 소속 |
1Department of Regenerative Medicine, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Gelatin; Pectin; biphasic calcium phosphate; BMP-2; VEGF
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| E-Mail |
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