| 초록 |
Ceria nanoparticles have received substantial attention in the field of biomedical applications due to their high activities, including antioxidant, antibacterial, and anticancer functions. In this work , the therapeutic outcomes of ceria nanorods (Ceria NRs) and ceria nanospheres (Ceria NSs) were demonstrated in an in vivostudy of mild traumatic brain injury (mTBI). Ceria nanoparticles significantly reduced FJB-positive cells and TUNEL-positive cells and restored mRNA levels of SOD1 and SOD2. They also decreased COX-2 expression compared with the untreated control group. Ceria NRs showed less stable and high-energy (100) and (110) planes, which increases the number of active sites.Ceria NRs (70.1 ± 0.5%) significantly decreased brain water content compared with Ceria NSs (73.7 ± 0.4%; p =0.0015), indicating that Ceria NRs are more effective in alleviating cerebral edema following in vivo mTBI. |
