| 초록 |
Plasmonic nanomaterials reveal noble optical properties for next-generation biosensors. Notably, an individual nanoparticle analysis can yield unique target information by LSPR. Based on the lab-on-a-particle technology, the next-generation biosensor is revolutionary for end-point detection (single or multiplex), and can be functionally extended to biological phenomena monitoring. We developed a new nanoplasmonic sensor to attain label-free, real-time, and cost-effective monitoring of the molecular interactions based on LSPR by analysis of epigenetics-driven transcriptional repression of DNA methylation, binding efficiency of normal polymerase with mutated DNA, and then normal promoter with mutated protein obtained from cancer cells. |
