| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
The investigation of the effects of micropatterns and cell-adhesive peptide on myoblast functions using enzyme-triggered hydrogels |
| 초록 |
Myoblast adhesion and formation of multinucleated myotube in anisotropic patterns are important steps during muscle regeneration processes. It is also well known that adhesion and growth of myoblasts are regulated by chemical and structural properties of underlying substrates. However, there has been no report on whether the influences of their factors are synergistic or independent to each other. Given that, we prepared peptide-incorporated hydrogels of (1) various peptide density (0.19 ± 0.04 to 0.89 ± 0.08 nmol/cm2) and (2) micro-scaled grooves with various widths (10, 25, 80 μm). When myoblasts were cultured on these hydrogels, we found that the adherent morphology, proliferation and differentiation were affected by peptide concentration and groove size, however, peptide concentration seems to be a dominant regulator on myoblast functions. |
| 저자 |
전인동1, 최은표2, 박정열2, 박경민3, 박기동3, 신흥수1
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| 소속 |
1한양대, 2서강대, 3아주대 |
| 키워드 |
in situ gelation; RGD peptide; micropatterning; hydrogel; enzyme polymerization; myoblast functions
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| E-Mail |
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