| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 봄 (04/24 ~ 04/26, 제주국제컨벤션센터) |
| 권호 |
25권 1호, p.719 |
| 발표분야 |
재료(Materials) |
| 제목 |
DNA cancer vaccine empowered by an injectable mesoporous silica microrods scaffold for cancer immunotherapy |
| 초록 |
DNA vaccine is one of the promising approaches in immunotherapy for the treatment of cancers. To induce an effective antigen-specific adaptive immune response, the DNAs coding the antigen are desired to be delivered into antigen-presenting cells (e.g., dendritic cells (DCs)); however, the effective delivery of DNAs to those cells is still limited. Here we propose an injectable porous scaffold to empower the efficacy of DNA vaccine by augmenting the DNA delivery to host DCs. Mesoporous silica rods (MSRs) were loaded with chemoattractant for the DCs and antigen-coded DNA-polyplex to prepare MSR-DNA vaccine. Subcutaneous injection of MSR-DNA vaccine resulted in the recruitment of a significant number of DCs, a high cellular uptake of antigen-coded DNA by the recruited DCs, and more robust host DCs activation and antigen-specific CD8+ T cells compared to the bolus DNA vaccine counterpart. Impressively, the vaccine significantly inhibited established lung metastasis with a single injection. Our results indicate that MSRs could serve as a powerful delivery platform of DNA vaccine to DCs for an effective cancer immunotherapy. |
| 저자 |
Nguyen Thanh Loc, Yue Yin, 최영진, 정지훈, 김재윤
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| 소속 |
성균관대 |
| 키워드 |
재료 |
| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
