| 학회 |
한국재료학회 |
| 학술대회 |
2010년 봄 (05/13 ~ 05/14, 삼척 팰리스 호텔) |
| 권호 |
16권 1호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Biocompatibility of oxidized alginate/gelatin/BCP –based hydrogel composites |
| 초록 |
In this study, oxidized alginate/gelatin/biphase calcium phosphate (BCP)- based hydrogel composites were fabricated. Alginate sodium was oxidized by periodate. The oxidized product was confirmed by using 1H and 13C NMR spectra. The number average molecular weight (Mn), the average molecular weight (Mw) of the oxidized alginate were determined by Gel Permeation Chromatography (GPC). The hydrogel was formed from the oxidized alginate and gelatin solution via Schift-base reaction. The hydrogel showed a highly porosity by a Scanning Electron Microscope (SEM) and Mercury Intrusion Porosimetry (MIP). Crosslinked density of the gel matrix were assessd by trinitrobenzene sulfonic acid (TNBS) assay that shows a high effect on swelling ratio. Increment of the crosslinked desity resulted in enhancing compressive strength of the hydrogel composite. The cytotoxity of hydrogel was assessed with osteoblast MG-63. The hydrogel composites show a high compatibility. The obtained results showed a potential application for bone regeneration in future. |
| 저자 |
Nguyen Thi Phuong1, Young Ki Min2, Hun Mo Yang3, Ho Yeon Song1, Byong-Teak Lee2
|
| 소속 |
1Department of Biomedical Engineering and Materials, 2School of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
hydrogel; oxidized alginate; gelatin; biphase calcium phosphate
|
| E-Mail |
|
